Overview Introduction Lupex-Plus Tablet is a combination of two medicines used to treat neuropathic pain. It works by protecting the nerve fibres against damage, repairing the damaged nerves. This way it effectively relieves the pain sensation and also elevates the mood. Lupex-Plus Tablet may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly. Some common side effects of this medicine include nausea, constipation, headache, insomnia (difficulty in sleeping), ejaculation disorder, erectile dysfunction, and low sexual desire. However, these are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you. You should avoid alcohol while taking Lupex-Plus Tablet, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Uses of Lupex-Plus Tablet Neuropathic pain Side effects of Lupex-Plus Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Lupex-Plus Nausea Constipation Headache Insomnia (difficulty in sleeping) Ejaculation disorder Erectile dysfunction Low sexual desire How to cope with side effects? The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist. Coping with Nausea You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve. Coping with Constipation Try to eat foods which are high in fiber such as fresh fruits, vegetables and cereals to increase the bulk and consistency of bowel movements. Drink plenty of water or non-alcoholic drinks and stay hydrated to promote healthy digestion. Increasing physical activities such as walking, yoga and regular exercise can also be helpful. If your condition does not improve, you can ask your doctor to prescribe you laxative medicine. Coping with Headache Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller. Coping with Ejaculation disorder and Erectile dysfunction Speak to your doctor as they may be able to change your medicine or offer other treatments that might help with the problem. Making healthy lifestyle changes and eating a healthy balanced diet can help. Lose weight if you are overweight. Exercise daily and try to reduce stress and anxiety. Avoid the use of alcohol, cigarettes or recreational drugs such as marijuana which can also affect sexual function. Counselling or psychotherapy can also be helpful. show more show less How to use Lupex-Plus Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lupex-Plus Tablet may be taken with or without food, but it is better to take it at a fixed time. How Lupex-Plus Tablet works Lupex-Plus Tablet is a combination of two medicines: Duloxetine and methylcobalamin. Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) which works by increasing the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibres and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves). Safety Advice Alcohol UNSAFE It is unsafe to consume alcohol with Lupex-Plus Tablet. Pregnancy CONSULT YOUR DOCTOR Lupex-Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Breastfeeding CONSULT YOUR DOCTOR Lupex-Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Driving UNSAFE Lupex-Plus Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Kidney CAUTION Lupex-Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Lupex-Plus Tablet may be needed. Please consult your doctor. Dose adjustment is not recommended in patients with mild and moderate kidney disease. Liver UNSAFE Lupex-Plus Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
